Please help: Jane's Phone is going to explode

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Jane
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Someone yesterday asked why I hadn't responded to an email from last week. Seriously, they get pushed down so fast, I sometimes don't even see them because they are three pages down. I have 18,223 unread emails in one single email account. I am going to get on top of this. Your suggestions would be helpful, as I know many of you deal with it too. Thanks in advance for any help. Xxo